Effects of phosphodiesterase inhibitors on interleukin-4 and interleukin-13 generation from human basophils

Effects of Interleukin-4 and Interleukin-13 on Bone

Human basophils express interleukin-4 receptors.

Interleukin-4 (IL-4), a multipotential lymphokine reputed to play an important role in the regulation of immune responses, interacts with a variety of hemopoietic target cells through specific cell surface membrane receptors. The present study was designed to investigate whether human basophils express IL-4 binding sites. For this purpose, basophils were enriched to homogeneity (93% and 98% pur...

Combination Effects of Prednisolone and Interleukin-4 Protect Bovine Nasal Cartilage Explants from Interleukin-1α Induced Degradation

Background: Current treatments for joint diseases are moderately successful, but unfortunately are associated with significant side effects. This study was undertaken to investigate the combination effects of IL-4 and prednisolone on tissue characteristics and production of matrix metalloproteinase-1(MMP-1) in IL-lα-treated bovine nasal cartilage (BNC) explants. Methods: BNC explants were cultu...

Protection of human conjunctival fibroblasts from NO-induced apoptosis by interleukin-4 or interleukin-13.

PURPOSE To examine the possible roles of T helper type 2 (Th2) cell-derived cytokines in formation of the giant papillae characteristic in individuals with vernal keratoconjunctivitis, the effects of these cytokines on the proliferation and apoptosis of cultured human conjunctival fibroblasts were investigated. METHODS Apoptosis was induced by the NO donor sodium nitroprusside. Cell viability...

Effects of interleukin 4 on monocyte functions: comparison to interleukin 13